The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2009
Filed:
Dec. 30, 2002
Dan Gazit, Jerusalem, IL;
Gadi Pelled, Rishon Leziyon, IL;
Gadi Turgeman, Jerusalem, IL;
Andrea Hoffmann, Hannover, DE;
Peter Eberle, Braunschweig, DE;
Gerhard Gross, Braunschweig, DE;
Dan Gazit, Jerusalem, IL;
Gadi Pelled, Rishon Leziyon, IL;
Gadi Turgeman, Jerusalem, IL;
Andrea Hoffmann, Hannover, DE;
Peter Eberle, Braunschweig, DE;
Gerhard Gross, Braunschweig, DE;
Abstract
This invention provides method for repairing, regenerating, treating, or inducing the repair of an injury, a defect or a condition of a connective tissue of a subject. This invention provides a method of regenerating, enhancing, inducing repair and/or development of connective tissue as a result of a defect, injury or condition of the connective tissue of a subject comprising the step of inserting an engineered cell which comprises a nucleic acid encoding a SMAD protein or variant thereof, so as to induce regeneration, repair and/or development of the connective tissue. This invention further provides methods of ex-vivo implantation of engineered cells into an injury, defect or condition of the connective tissue. This invention also provides a nucleic acid encoding a SMAD 8 protein variant, cells comprising such SMAD 8 variant, include mesenchymal stem cells, progenitor cells or cells derived from a connective tissue. Lastly, this invention provides SMAD 8 protein variant.