The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2009
Filed:
Mar. 09, 2005
Samuel I. Achilefu, St. Louis, MO (US);
Raghavan Rajagopalan, Solon, OH (US);
Richard B. Dorshow, St. Louis, MO (US);
Joseph E. Bugaj, Richmond, CA (US);
Muthunadar P. Periasamy, Chesterfield, MO (US);
Samuel I. Achilefu, St. Louis, MO (US);
Raghavan Rajagopalan, Solon, OH (US);
Richard B. Dorshow, St. Louis, MO (US);
Joseph E. Bugaj, Richmond, CA (US);
Muthunadar P. Periasamy, Chesterfield, MO (US);
Mallinkrodt Inc., Hazelwood, MO (US);
Abstract
Cyanine and Indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of compounds of the invention allows favorable delivery to tumor cells as compared to larger molecular weight imaging agents. Further, use of a biocompatible organic solvent such as dimethylsulfoxide may be said to assist in maintaining the fluorescence of compounds of the invention. The compounds and bioconjugates herein disclosed are useful in a variety of medical applications including, but not limited to, diagnostic imaging and therapy, endoscopic applications for the detection of tumors and other abnormalities, localized therapy, photoacoustic tumor imaging, detection and therapy, and sonofluorescence tumor imaging, detection and therapy.