The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2009
Filed:
Jun. 30, 2006
Joseph Floyd Clark, Cincinnati, OH (US);
Thomas Andrew Daniel Cadoux-hudson, Oxford, GB;
Christopher Joseph Schofield, Oxford, GB;
Joseph Floyd Clark, Cincinnati, OH (US);
Thomas Andrew Daniel Cadoux-Hudson, Oxford, GB;
Christopher Joseph Schofield, Oxford, GB;
Medical Research Council, London, GB;
Abstract
A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Yis hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SOR, —COR, —CONHRor —COR, and each of R, Rand R, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, or a compound of formula (II) wherein each of Yand Y, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SOR, —COR, —CONHRor —COR, Z is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, —CH═C(NHR)CH((CH)m COR)(C═O)CHor —CH(C═O)CH((CH)COR)(C═O)CH, Ris —(CH)COR, each of Rto Rand Rto R, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and each of m and n, which may be the same or different, is 1 to 6 or a compound of formula (III) wherein each of Yto Y, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SOR, —COR, —CONHRor —COR, each of Rand R, which may be the same or different, is —(CH)p COR, each of Rto Rand Rto R, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and p is 1 to 6, or other photolabile degradation product of bilirubin or biliverdin or derivative of a photolabile degradation fragment of bilirubin or biliverdin, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier or diluent.