The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2009
Filed:
Oct. 14, 2005
Daved H. Fremont, St. Louis, MO (US);
Grant Nybakken, St. Louis, MO (US);
Michael Diamond, St. Louis, MO (US);
Daved H. Fremont, St. Louis, MO (US);
Grant Nybakken, St. Louis, MO (US);
Michael Diamond, St. Louis, MO (US);
Washington University, St. Louis, MO (US);
Abstract
The present invention provides crystalline forms of domain III of the West Nile Virus ('WNV') envelope protein in complex with a Fab fragment of a neutralizing antibody, methods of obtaining such crystals and high-resolution structures and atomic structure coordinates. The crystals of the invention and the atomic structural information are useful for solving crystal and solution structures of related and unrelated proteins, and for screening for, identifying or designing compounds or antibodies that bind to, modulate a biological activity of, or neutralize infection mediated by flaviviral envelope proteins.