The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2009
Filed:
Jul. 18, 2006
Applicant:
Shengfeng LI, Belmont, CA (US);
Inventor:
Shengfeng Li, Belmont, CA (US);
Assignee:
Humab Solutions, Inc., Foster City, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides improved tPA variants having significantly reduced susceptibility to inhibition and increased affinity for platelet integrin as compared with the wild-type tPA. The present invention also provides compositions comprising the tPA variants and polynucleotides, vectors, and host cells for producing the same as well as methods of using these tPA variants to treat disease conditions, e.g., thrombotic disorders.