The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 24, 2009
Filed:
Apr. 05, 2005
Yi Xiao, Fanwood, NJ (US);
Yongkui Sun, Bridgewater, NJ (US);
Thorsten Rosner, Berkeley Heights, NJ (US);
Nelo R. Rivera, New Milford, NJ (US);
Shane W. Krska, New Providence, NJ (US);
Andrew M. Clausen, Westfield, NJ (US);
Joseph D. Armstrong, Iii, Westfield, NJ (US);
Felix Spindler, Starrkirch-Wil, CH;
Christophe Malan, Neuchatel, CH;
Yi Xiao, Fanwood, NJ (US);
Yongkui Sun, Bridgewater, NJ (US);
Thorsten Rosner, Berkeley Heights, NJ (US);
Nelo R. Rivera, New Milford, NJ (US);
Shane W. Krska, New Providence, NJ (US);
Andrew M. Clausen, Westfield, NJ (US);
Joseph D. Armstrong, III, Westfield, NJ (US);
Felix Spindler, Starrkirch-Wil, CH;
Christophe Malan, Neuchatel, CH;
Solvias AG, Basel, CH;
Merck & Co., Inc., Rahway, NJ (US);
Abstract
The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.