The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 24, 2009

Filed:

Sep. 01, 2006
Applicants:

Chandan Singh, Lucknow, IN;

Heetika Malik, Lucknow, IN;

Sunil Kumar Puri, Lucknow, IN;

Inventors:

Chandan Singh, Lucknow, IN;

Heetika Malik, Lucknow, IN;

Sunil Kumar Puri, Lucknow, IN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/357 (2006.01); C07D 323/06 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to spiro 1,2,4-trioxanes of general formula 4. This invention more particularly relates to a process for the preparation of a series of spiro 1,2,4-trioxanes. Wherein, Ar represents aryl groups such as phenyl, 4-biphenyl, 4-chlorophenyl, 4-methoxyphenyl, 4-methylphenyl, 4-cyclohexylphenyl, 1-naphthyl, 2-naphthyl and the like and R represents hydrogen or the alkyl group such as methyl, ethyl and the like. Several of these compounds show high order of antimalarial activity against multidrug-resistant malaria in mice and thus hold promise as antimalarial agents against multidrug-resistant malaria.


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