Agent for treating respiratory diseases containing 4-hydroxypiperidine derivative as active ingredient

Abstract

An agent for preventing/treating respiratory diseases contains, as an active ingredient, a compound represented by following Formula (I): wherein A is a group represented by L-W [wherein L is a bond or CH; and W is O, SOn (wherein n is 0 to 2), or —NR— (wherein Ris hydrogen or lower alkyl)]; each of Gand Gis (CH)r (wherein r is 0 to 2), provided that when n is 1, Gand Gmay be bridged by lower alkylene; Y is a lower alkylene or (substituted) benzylidene; Z is a bond or O, provided that when Z is a bond, Y may form a 5- or 6-membered ring with carbon on the benzene ring; Ris, for example, NO, a lower alkoxycarbonyl, (substituted) carbamoyl, (protected) hydroxyl group, (protected) carboxyl, or (protected) N-hydroxycarbamoyl; each of Rand Ris hydrogen, halogen, (halogenated) lower alkyl, (halogenated) lower alkoxy or NO; each of Rand Ris, for example, hydrogen, halogen, (halogenated) lower alkyl, (halogenated) lower alkoxy, CN, or lower alkylsulfonyl; and Ris hydrogen or lower alkyl, a salt thereof or a solvate of them. It has excellent antitussive activity when used as an agent for preventing/treating respiratory diseases such as lung cancer, common cold syndrome, pulmonary tuberculosis, pneumonia, acute bronchitis or chronic bronchitis.