The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 24, 2009
Filed:
May. 15, 2002
Dennis P. Orgill, Belmont, MA (US);
Quentin Gavin Eichbaum, Watertown, MA (US);
Sui Huang, Boston, MA (US);
Chao-wei Hwang, Brookline, MA (US);
Donald E. Ingber, Boston, MA (US);
Vishal Saxena, Cambridge, MA (US);
Evan Stuart Garfein, Boston, MA (US);
Dennis P. Orgill, Belmont, MA (US);
Quentin Gavin Eichbaum, Watertown, MA (US);
Sui Huang, Boston, MA (US);
Chao-Wei Hwang, Brookline, MA (US);
Donald E. Ingber, Boston, MA (US);
Vishal Saxena, Cambridge, MA (US);
Evan Stuart Garfein, Boston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
Methods and devices for transmitting micromechanical forces locally to induce surface convolutions into tissues on the millimeter to micron scale for promoting wound healing are presented. These convolutions induce a moderate stretching of individual cells, stimulating cellular proliferation and elaboration of natural growth factors without increasing the size of the wound. Micromechanical forces can be applied directly to tissue, through biomolecules or the extracellular matrix. This invention can be used with biosensors, biodegradable materials and drug delivery systems. This invention will also be useful in pre-conditioned tissue-engineering constructs in vitro. Application of this invention will shorten healing times for wounds and reduce the need for invasive surgery.