The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2009
Filed:
Jul. 12, 2002
Qijun Qian, Shanghai 200438, CN;
Mengchao Wu, Shanghai, CN;
Shuntong Shan, Shanghai, CN;
Other;
Abstract
The present invention provides a recombinant virus, which highly expresses a cancer therapeutic gene and specifically proliferates in tumor cells, and a method for the proliferation of the same. In said recombinant virus, the transcription of at least one VPEG is under the control of a hTERT promoter, whereby the virus selectively proliferates in telomerase activity positive tumor cells, but substantially not in normal cells negative in the telomerase activity. Said recombinant virus further contains a cancer therapeutic gene inserted in its genome, whereby the cancer therapeutic gene is highly expressed in tumor cells. The tumor cells are killed by the synergistic effects of the virus and the cancer therapeutic gene. Such recombinant viruses can be used to treat various tumors.