The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2009
Filed:
Sep. 12, 2005
Applicants:
Roland Contreras, Merelbeke, BE;
Steven Geysens, Kruishoutem, BE;
Inventors:
Roland Contreras, Merelbeke, BE;
Steven Geysens, Kruishoutem, BE;
Assignees:
Vlaams Interuniversitair Institute voor Biotechnologie vzw, Zwijnaarde, BE;
Universiteit Gent, Gent, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/02 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to the use of a glucosidase II mutation to increase protein secretion in eukaryotic cells. The present invention relates further to the use of eukaryotic cells, comprising a mutant glucosidase II gene, possibly in combination with the expression of a recombinant α-1,2-mannosidase gene and/or a recombinant N-acetylglucosaminyl-transferase gene, as a host for protein secretion.