The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2009
Filed:
May. 19, 2003
Kuo-fen Lee, Del Mar, CA (US);
Wylie Vale, La Jolla, CA (US);
Chien LI, San Diego, CA (US);
Lingyun Zhao, San Diego, CA (US);
Douglas E. Vetter, Boston, MA (US);
Kuo-Fen Lee, Del Mar, CA (US);
Wylie Vale, La Jolla, CA (US);
Chien Li, San Diego, CA (US);
Lingyun Zhao, San Diego, CA (US);
Douglas E. Vetter, Boston, MA (US);
Research Development Foundation, Carson City, NV (US);
Abstract
The present invention provides transgenic mice deficient in urocortin. Urocortin null mutant mice are hypersensitive to stress and display heightened anxiety-like behaviors in the elevated plus maze and open field tests. These mice also demonstrate physiological alterations in auditory thresholds and distortion product otoacoustic emissions. These results indicate that urocortin plays a modulatory role in anxiety-related behaviors and in contributing to the establishment of auditory thresholds. Such urocortin deficient mutant mice can provide useful models in the study of anxiety pathology and hearing physiology at the biochemical and molecular levels.