The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2009
Filed:
Aug. 25, 2003
Applicants:
Erkki Ruoslahti, Rancho Santa Fe, CA (US);
Markus Essler, München, DE;
Darren M. Brown, San Diego, CA (US);
Inventors:
Erkki Ruoslahti, Rancho Santa Fe, CA (US);
Markus Essler, München, DE;
Darren M. Brown, San Diego, CA (US);
Assignee:
Burnham Institute for Medical Research, La Jolla, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 5/00 (2006.01); C07K 7/06 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides a conjugate containing a therapeutic agent linked to a homing molecule that selectively homes to tumor vasculature and selectively binds collagen such as non-helical collagen or collagen IV. In one embodiment, the conjugate contains a homing peptide or peptidomimetic that includes the amino acid sequence CREKA (SEQ ID NO: 1) or a conservative variant or peptidomimetic thereof.