The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2009
Filed:
Sep. 30, 2004
Dale S. Dhanoa, Wakefield, MA (US);
Oren Becker, Mevaseret Zion, IL;
Silvia Noiman, Herzliya, IL;
Pradyumna Mohanty, Woburn, MA (US);
Dongli Chen, Chestnut Hill, MA (US);
Mercedes Lobera, Concord, MA (US);
Laurence Wu, Woburn, MA (US);
Yael Marantz, Kadima, IL;
Boaz Inbal, Kfar Shmuel, IL;
Alexander Heifetz, Bnei-Brak, IL;
Shay Bar-haim, Netanya, IL;
Sharon Shacham, Alfey Menashe, IL;
Dale S. Dhanoa, Wakefield, MA (US);
Oren Becker, Mevaseret Zion, IL;
Silvia Noiman, Herzliya, IL;
Pradyumna Mohanty, Woburn, MA (US);
Dongli Chen, Chestnut Hill, MA (US);
Mercedes Lobera, Concord, MA (US);
Laurence Wu, Woburn, MA (US);
Yael Marantz, Kadima, IL;
Boaz Inbal, Kfar Shmuel, IL;
Alexander Heifetz, Bnei-Brak, IL;
Shay Bar-Haim, Netanya, IL;
Sharon Shacham, Alfey Menashe, IL;
Epix Delaware, Inc., Wilmington, DE (US);
Abstract
The invention relates to 5-HT receptor agonists and partial agonists. Thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.