The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2009
Filed:
Oct. 28, 2002
Steven E. Ealick, Ithaca, NY (US);
William B. Parker, Birmingham, AL (US);
John A. Secrist, Iii, Birmingham, AL (US);
Eric J. Sorscher, Birmingham, AL (US);
Steven E. Ealick, Ithaca, NY (US);
William B. Parker, Birmingham, AL (US);
John A. Secrist, III, Birmingham, AL (US);
Eric J. Sorscher, Birmingham, AL (US);
Cornell Center for Technology Enterprise and Commercialization, Ithaca, NY (US);
The UAB Research Foundation, Birmingham, AL (US);
Southern Research Institute, Birmingham, AL (US);
Abstract
A host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside cleavage enzymes is provided. The transformed or transfected host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells. A nucleotide sequence encoding mutantderived purine nucleoside phosphorylase proteins which can be used in conjunction with an appropriate substrate to produce toxins which impair abnormal cell growth is also provided. A method is detailed for the delivery of toxin by generation within target cells or by administration and delivery to the cells from without. Novel purine nucleosides are detailed that yield a cytotoxic purine upon enzymatic cleavage. A synthetic process for nucleosides is also detailed.