The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2009
Filed:
Nov. 14, 2000
Matti Airaksinen, Helsinki, FI;
Mart Saarma, Helsinki, FI;
Dimitri Poteriaev, Helsinki, FI;
Maria Lindahl, Espoo, FI;
Tönis Timmusk, Helsinki, FI;
Jari Rossi, Helsinki, FI;
Matti Airaksinen, Helsinki, FI;
Mart Saarma, Helsinki, FI;
Dimitri Poteriaev, Helsinki, FI;
Maria Lindahl, Espoo, FI;
Tönis Timmusk, Helsinki, FI;
Jari Rossi, Helsinki, FI;
Licentia Ltd., Helsinki, FI;
Abstract
The present invention discloses purified and isolated nucleic acid sequences encoding polypeptides having a structure substantially similar to that of splicing forms of mammalian GFRα4 comprising the amino acid sequence (SEQ ID NO:1:)-(SEQ ID NO:6:). The preferred sequences comprise cDNAs having the sequence (SEQ ID NO:7:)-(SEQ ID NO:13:). The present invention is also related to purified and isolated polypeptides comprising the amino acid sequence and or substantially similar splicing forms of mammalian GFRà4. Furthermore, the invention is related to substances capable of specifically recognizing said polypeptides and including both antibodies and receptors. The active compounds of the present invention including cDNAS, polypeptides, binding substances, and antibodies. The invention is useful not only for producing cell-lines and/or transgenic non-human animal but also for diagnosing and treating neuronal disorders or endocrine tumors as well as other related diseases by enabling measurements of GFRα4-mediated signalling in endocrine cells and neurons.