The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2009
Filed:
Jun. 26, 2003
Richard Anthony Lang, Loveland, OH (US);
Ivan Borisovich Lobov, New York, NY (US);
Richard Anthony Lang, Loveland, OH (US);
Ivan Borisovich Lobov, New York, NY (US);
Children's Hospital Medical Center, Cincinnati, OH (US);
Abstract
A method for evaluating in vivo a test substance for angiogenesis modulation activity, including the steps of providing a rodent pup having a pupillary membrane system in a first eye, injecting transcorneally proximate to the pupillary membrane a test substance; and examining the pupillary membrane to determine whether new vascular tissue has grown. The method can also evaluate the ability of a test substance to regress existing vascular tissue, or to inhibit or prevent new vascular tissue, by injecting transcorneally a first substance that induces new vascular tissue growth, then injecting a test substance, and examining the pupillary membrane to determine whether new vascular tissue has grown. The assay can also be used to evaluate the effect of a small molecule on a property of a capillary vessel, and to evaluate a test substance on a problematic vascular condition.