The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2009
Filed:
Apr. 02, 2004
Young Hoon Park, Gyeonggi-do, KR;
Byoung Choon Lee, Seoul, KR;
Dae Cheol Kim, Gyeonggi-do, KR;
Jin Ho Lee, Gyeonggi-do, KR;
Jae Yong Cho, Gyeonggi-do, KR;
Young Hoon Park, Gyeonggi-do, KR;
Byoung Choon Lee, Seoul, KR;
Dae Cheol Kim, Gyeonggi-do, KR;
Jin Ho Lee, Gyeonggi-do, KR;
Jae Yong Cho, Gyeonggi-do, KR;
CJ Cheiljedang Corporation, Seoul, KR;
Abstract
The present invention provide a microorganism comprising an inactivated chromosomal tdcBC gene and an inactivated chromosomal pckA gene, which has remarkably improved productivity of L-threonine. Also, the present invention provides a method of producing L-threonine using the microorganism. The microorganism is prepared by incorporating by a recombination technique an antibiotic resistance gene into a pckA gene on the chromosome of a bacterial strain containing an L-threonine degradation-associated operon gene, tdcBC, which is inactivated. The microorganism has the effect of preventing degradation and intracellular influx of L-threonine due to the inactivation of the tdcBC operon gene, and includes more activated pathways for L-threonine biosynthesis. Therefore, the microorganism is useful for mass production of L-threonine because of being capable of producing L-threonine in high levels and high yields even in the presence of high concentrations of glucose.