The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2009
Filed:
Aug. 09, 2005
Applicants:
Clive R. Wood, Cambridge, MA (US);
Daniel T. Dransfield, Hanson, MA (US);
Henk Pieters, Maastricht, NL;
Rene Hoet, Maastricht, NL;
Simon E. Hufton, Clitheroe, GB;
Inventors:
Clive R. Wood, Cambridge, MA (US);
Daniel T. Dransfield, Hanson, MA (US);
Henk Pieters, Maastricht, NL;
Rene Hoet, Maastricht, NL;
Simon E. Hufton, Clitheroe, GB;
Assignee:
Dyax Corp., Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); C07K 16/00 (2006.01); C12P 21/08 (2006.01); G01N 33/53 (2006.01);
U.S. Cl.
CPC ...
Abstract
Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.