The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 27, 2009

Filed:

Jan. 08, 2003
Applicants:

Henryk Struszczyk, Zgierz, PL;

Antoni Niekraszewicz, Lodz, PL;

Magdelena Kucharska, Lodz, PL;

Alojzy Urbanowski, Lodz, PL;

Maria Wisniewska-wrona, Lodz, PL;

Ewa Wesolowska, Lodz, PL;

Danuta Ciechanska, Lodz, PL;

Inventors:

Henryk Struszczyk, Zgierz, PL;

Antoni Niekraszewicz, Lodz, PL;

Magdelena Kucharska, Lodz, PL;

Alojzy Urbanowski, Lodz, PL;

Maria Wisniewska-Wrona, Lodz, PL;

Ewa Wesolowska, Lodz, PL;

Danuta Ciechanska, Lodz, PL;

Assignee:

Abbott Laboratories, Abbott Park, IL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 36/06 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are methods of producing modified microcrystalline chitosan. Chitosan in aqueous solution is degraded enzymatically, hydrolytically or oxidatively. The chitosan solution is then alkalized with agitation using aqueous hydroxides and/or their salts to attain a pH not lower than 7.0. The precipitated modified microcrystalline chitosan is highly pure and may be concentrated and dried according to known methods. Methods according to the invention also include methods by which an aqueous solution of chitosan is first alkalized using hydroxides and/or their salts to a pH not lower than 7.0. Then the precipitated microcrystalline chitosan is subjected to enzymatic or oxidative degradation to achieve a desired average molecular weight and polydispersity. The product is highly pure and may be concentrated and dried according to known methods.


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