The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 20, 2009
Filed:
Mar. 17, 2005
Michael Aaron Brodney, East Lyme, CT (US);
Stephane Caron, Stonington, CT (US);
Christopher John Helal, East Lyme, CT (US);
Jeffrey W. Raggon, North Stonington, CT (US);
Yong Tao, Salem, CT (US);
Nga M. DO, Groton, CT (US);
Michael Aaron Brodney, East Lyme, CT (US);
Stephane Caron, Stonington, CT (US);
Christopher John Helal, East Lyme, CT (US);
Jeffrey W. Raggon, North Stonington, CT (US);
Yong Tao, Salem, CT (US);
Nga M. Do, Groton, CT (US);
Pfizer Inc., New York, NY (US);
Abstract
The present invention relates to novel benzyl(idene)-lactam derivatives, compounds of the formula I wherein Ris a group of the formula Gor Gdepicted below, wherein R, R, R, RX, a, n and m are as defined herein, their pharmaceutically acceptable salts, and pharmaceutical compositions which include selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT) receptors, specifically, of one or both of the 5-HTand 5-HTreceptors. The compounds of the invention are useful in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which a 5-HTagonist or antagonist is indicated and have reduced potential for cardiac side effects, in particular QTc prolongation.