The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 20, 2009
Filed:
Feb. 18, 2004
James M. Binley, Brooklyn, NY (US);
Norbert Schuelke, New City, NY (US);
William C. Olson, Ossining, NY (US);
Paul J. Maddon, Scarsdale, NY (US);
John P. Moore, New York, NY (US);
James M. Binley, Brooklyn, NY (US);
Norbert Schuelke, New City, NY (US);
William C. Olson, Ossining, NY (US);
Paul J. Maddon, Scarsdale, NY (US);
John P. Moore, New York, NY (US);
Progenics Pharmaceuticals, Inc., Tarrytown, NY (US);
Aaron Diamond AIDS Research Centre (ADARC), New York, NY (US);
Abstract
This invention provides a DNA which upon transcription produces an RNA encoding a modified HIV-1 gp140 polypeptide, which polypeptide upon cleavage produces a modified gp120 and a modified ectodomain of gp41 which together form a complex exhibiting enhanced binding to HIV-1 neutralizing antibodies and reduced binding to HIV-1 non-neutralizing antibodies, wherein the modifications comprise an A492C mutation in gp120 and a T596C mutation in gp41, said mutations being numbered by reference to the HIV-1 isolate JR-FL, and resulting in a disulfide bond between gp120 and ectodomain gp41 which stabilizes the otherwise non-covalent gp120-gp41 interaction.