The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 2009
Filed:
Jul. 19, 2007
Karin Maria Balss, King of Prussia, PA (US);
Gerard Llanos, Stewartsville, NJ (US);
Cynthia Anne Maryanoff, New Hope, PA (US);
George Papandreou, Kendall Park, NJ (US);
Vladimir Veselov, Newtown, PA (US);
Karin Maria Balss, King of Prussia, PA (US);
Gerard Llanos, Stewartsville, NJ (US);
Cynthia Anne Maryanoff, New Hope, PA (US);
George Papandreou, Kendall Park, NJ (US);
Vladimir Veselov, Newtown, PA (US);
Cordis Corporation, Miami Lakes, FL (US);
Abstract
A method and system for the non-destructive analysis of medical devices uses a confocal Raman microscope and other non-destructive analytical tools to assess the spatial distribution of components of an object such as the distribution of an active pharmaceutical ingredient (API) within a polymer matrix. In a preferred embodiment, confocal Raman spectroscopy was used to differentiate each component found in the sirolimus-eluting coronary stent. The unique spectral features identified for each component were then used to develop three separate calibration curves to describe the solid phase distribution found on drug-polymer coated stents. The calibration curves were obtained by analyzing confocal Raman spectral depth profiles from a set of 16 unique formulations of drug-polymer coatings sprayed onto stents and planar substrates.