The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 2009
Filed:
May. 06, 2005
Bernardo Herradon Garcia, Madrid, ES;
Mercedes Alonso Giner, Madrid, ES;
Esperanza Benito Cano, Madrid, ES;
Antonio Chana Lopez, Madrid, ES;
Ana Montero Aguado, Madrid, ES;
Bernardo Herradon Garcia, Madrid, ES;
Mercedes Alonso Giner, Madrid, ES;
Esperanza Benito Cano, Madrid, ES;
Antonio Chana Lopez, Madrid, ES;
Ana Montero Aguado, Madrid, ES;
Consejo Superior de Investigaciones Cientificas, Madrid, ES;
Abstract
The present invention relates to compounds derived from biphenyl with activity as calpain inhibitors. One compound of the present invention is a 2,2'-disubstituted biphenyl, where the substituents in the 2 and 2′ positions of the biphenyl skeleton are chains containing structures related to amino acids, including fragments of aminocarbonylic compounds where at least one of the substituents in said 2- or 2′-positions is bonded to the biphenyl skeleton via a thiocarbonyl group, forming compounds with thioamide functionality. The present invention also encompasses any of the conformational isomers (atropisomers) of said compound of formula I. The compounds of formula I have application in the preventive or therapeutic treatment of a degenerative disease.