The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 2009
Filed:
Sep. 21, 2006
Marie Dutreix, L'Hay les Roses, FR;
Jian-sheng Sun, Saint Maur des Fosses, FR;
Marie Dutreix, L'Hay les Roses, FR;
Jian-Sheng Sun, Saint Maur des Fosses, FR;
Institut Curie, Paris Cedex, FR;
Centre National de la Recherche Scientifique (CNRS), Paris Cedex, FR;
Museum National d'Histoire Naturelle, Paris Cedex, FR;
Institut National de la Sante Et de la Recherche Medicale (INSERM), Paris Cedex, FR;
Abstract
The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumor cell nuclei in order to neutralize transiently their DNA repair capacity and trigger their death.