The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 2009
Filed:
Sep. 12, 2005
Sangita Phadtare, Highland Park, NJ (US);
Kunitoshi Yamanaka, Highland Park, NJ (US);
Ikunoshin Kato, Kyoto, JP;
Masayori Inouye, Piscataway, NJ (US);
Sangita Phadtare, Highland Park, NJ (US);
Kunitoshi Yamanaka, Highland Park, NJ (US);
Ikunoshin Kato, Kyoto, JP;
Masayori Inouye, Piscataway, NJ (US);
Takara Bio Inc., , JP;
Abstract
The invention relates to a gene isolated from, dep, which confers resistance to the antibacterial activity of 4,5-dihydroxy-2-cyclopenten-1-one (DHCP). The invention further relates to the putative protein encoded by dep, which is a hydrophobic, transmembrane efflux protein specific for DHCP. The invention further relates to plasmids containing the dep gene, and to bacterial cells expressing dep. Furthermore, the invention provides applications for use in conferring resistance to antibacterial activity in organisms. The dep gene can be used to identify compounds which inhibit the efflux activity responsible for the resistance to DHCP or to compounds which are functionally equivalent to DHCP.