The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 2009
Filed:
Jun. 09, 2005
Gerald P. Murphy, Seattle, WA (US);
Alton L. Boynton, Bethesda, MD (US);
Eric H. Holmes, Bothell, WA (US);
William T. Tino, Redmond, WA (US);
Gerald P. Murphy, Seattle, WA (US);
Alton L. Boynton, Bethesda, MD (US);
Eric H. Holmes, Bothell, WA (US);
William T. Tino, Redmond, WA (US);
Medarex, Inc., Princeton, NJ (US);
Abstract
The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM') of PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM′ allows the use of an immunoenzymatic assay for their detection.