The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 2009
Filed:
Mar. 07, 2003
Roland Kreutzer, Weidenberg, DE;
Stefan Limmer, Neudrossenfeld, DE;
Hans-peter Vornlocher, Bayreuth, DE;
Philipp Hadwiger, Bayreuth, DE;
Anke Geick, Bayreuth, DE;
Matthias Ocker, Erlangen, DE;
Christoph Herold, Erlangen, DE;
Detlef Schuppan, Bubenreuth, DE;
Roland Kreutzer, Weidenberg, DE;
Stefan Limmer, Neudrossenfeld, DE;
Hans-Peter Vornlocher, Bayreuth, DE;
Philipp Hadwiger, Bayreuth, DE;
Anke Geick, Bayreuth, DE;
Matthias Ocker, Erlangen, DE;
Christoph Herold, Erlangen, DE;
Detlef Schuppan, Bubenreuth, DE;
Alnylam Europe AG, Cambridge, MA (US);
Abstract
The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an anti-apoptotic gene, comprising a complementary RNA strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially identical to at least a part of an apoptotic gene, such as a Bcl gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of an anti-apoptotic gene using the pharmaceutical composition; and methods for inhibiting the expression of an anti-apoptotic gene in a cell.