The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2008
Filed:
Jun. 30, 2005
Jeffrey S. Bishop, Spring, TX (US);
A. Katrina Loomis, Houston, TX (US);
Daniel J. Monticello, The Woodlands, TX (US);
Philip T. Pienkos, The Woodlands, TX (US);
Jeffrey S. Bishop, Spring, TX (US);
A. Katrina Loomis, Houston, TX (US);
Daniel J. Monticello, The Woodlands, TX (US);
Philip T. Pienkos, The Woodlands, TX (US);
Molecular Logix, Inc., The Woodlands, TX (US);
Abstract
The present invention features epidermal growth factor receptor (EGFR) antagonists. These EGFR antagonists are polypeptide variants of ligands of EGFR. The EGFR ligand polypeptide variants of the invention possess EGFR antagonistic properties and can inhibit at least one EGFR-mediated biological activity such as inhibition of the receptor's kinase activation activity and subsequently, cell proliferation. Such polypeptide variants, and nucleic acids encoding these polypeptide variants can be used therapeutically in situations in which inhibition of EGFR activity is indicated.