The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2008
Filed:
Jan. 21, 2005
Lijun Sun, Harvard, MA (US);
Mitsunori Ono, Lexington, MA (US);
Elena Kostik, Arlington, MA (US);
Yumiko Wada, Billerica, MA (US);
Lijun Sun, Harvard, MA (US);
Mitsunori Ono, Lexington, MA (US);
Elena Kostik, Arlington, MA (US);
Yumiko Wada, Billerica, MA (US);
Synta Pharmaceuticals Corp., Lexington, MA (US);
Abstract
This invention features pyrimidine compounds of formula (I): Ris in which one of Rand Ris H or alkyl, and the other is aryl or heteroaryl optionally substituted with Rand R; each of Rand Ris H; Ris H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; Ris H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NR; Y is covalent bond, CH, C(O), C═N—R, C═N—OR, C═N—SR, O, S, S(O), S(O), or NR; Z is N or CH; one of U and V is N, and the other is CR; and W is O, S, S(O), S(O), NR, or NC(O)R; in which Ris H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; Ris halogen, CN, alkyl, alkyloxy, alkylcarbonyl, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, hydroxyalkyl, alkylamino, or alkylaminocarbonyl; Ris halogen, CN, hydroxyl, alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, or heteroaryloxyl; and m is 0, 1, 2, 3, or 4. The pyrimidine compounds can be used to treat an IL-12 overproduction-related disorder (e.g., rheumatoid arthritis, sepsis, Crohn's disease, multiple sclerosis, psoriasis, or insulin-dependent diabetes mellitus).