The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2008
Filed:
Oct. 21, 2005
Darren H. Wakefield, Fitchburg, WI (US);
David B. Rozema, Madison, WI (US);
Jon A. Wolff, Madison, WI (US);
Vladimir Trubetskoy, Middleton, WI (US);
James E. Hagstrom, Middleton, WI (US);
Vladimir G. Budker, Middleton, WI (US);
Jason Klein, Madison, WI (US);
SO Wong, Oregon, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
David B. Rozema, Madison, WI (US);
Jon A. Wolff, Madison, WI (US);
Vladimir Trubetskoy, Middleton, WI (US);
James E. Hagstrom, Middleton, WI (US);
Vladimir G. Budker, Middleton, WI (US);
Jason Klein, Madison, WI (US);
So Wong, Oregon, WI (US);
Abstract
Polyampholyte are able to condense nucleic acid to form small complexes which can be utilized in the delivery of nucleic acid to mammalian cells. The polyampholytes can be formed prior to interaction with nucleic acid or they can be formed in the presence of nucleic acid. Stabilized polycation/nucleic acid complexes can be modified to reduce the positive charge of the polycation and add targeting ligands without destabilizing the complex. The resultant particles retain their small size and are more effective in delivery of nucleic acid to cells in vivo.