The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2008
Filed:
Dec. 21, 2001
John Wyrick, Spokane, CA (US);
Richard A. Young, Weston, MA (US);
Bing Ren, San Diego, CA (US);
Francois Robert, Boston, MA (US);
Itamar Simon, Brighton, MA (US);
John Wyrick, Spokane, CA (US);
Richard A. Young, Weston, MA (US);
Bing Ren, San Diego, CA (US);
Francois Robert, Boston, MA (US);
Itamar Simon, Brighton, MA (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Abstract
The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to which the DNA binding protein is linked is removed and combined or contacted with DNA comprising a sequence complementary to genomic DNA of the cell under conditions in which hybridization between the identified genomic DNA and the sequence complementary to genomic DNA occurs. Region(s) of hybridization are region(s) of the genome of the cell to which the protein of binds. A method of identifying a set of genes where cell cycle regulator binding correlates with gene expression and of identifying genomic targets of cell cycle transcription activators in living cells is also encompassed.