The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 23, 2008
Filed:
Mar. 15, 2004
Yi Xiao, Fanwood, NJ (US);
Joseph D. Armstrong, Iii, Westfield, NJ (US);
Shane W. Krska, New Providence, NJ (US);
Eugenia Njolito, Princeton, NJ (US);
Nelo R. Rivera, New Milford, NJ (US);
Yongkui Sun, Bridgewater, NJ (US);
Thorsten Rosner, North Plainfield, NJ (US);
Yi Xiao, Fanwood, NJ (US);
Joseph D. Armstrong, III, Westfield, NJ (US);
Shane W. Krska, New Providence, NJ (US);
Eugenia Njolito, Princeton, NJ (US);
Nelo R. Rivera, New Milford, NJ (US);
Yongkui Sun, Bridgewater, NJ (US);
Thorsten Rosner, North Plainfield, NJ (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.