The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2008
Filed:
Dec. 20, 2004
Sandeep Gulati, La Canada Flintridge, CA (US);
Sandeep Gulati, La Canada Flintridge, CA (US);
ViaLogy LLC, Altadena, CA (US);
Abstract
The current invention discloses a novel spectral transformation technique for characterizing digitized intensity output patterns from microarrays. This method yields improved sensitivity with reduced false positives and false negatives. Current microarray methods are overly sensitive to the detection of a visible distinction between pixels associated with probes and pixels associated with background. In one embodiment, a technique is disclosed that comprises the steps of: extracting pixels associated with an object of interest and transforming such pixels from an intensity representation to a spectral representation. In some embodiments, the extraction is based on a tessellated logarithmic spiral extraction that may yield a pixel core with a sampling of both foreground and background pixels. This core may then be computationally rescaled by 10×-10,000× to enhance spatial resolution. Once the extracted pixels are represented in the spectral regime, convolution with resolution-enhancement kernels may be used to accentuate morphological features capturing platform specific phenomenology.