The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 16, 2008

Filed:

Aug. 11, 2006
Applicants:

Amedeo A. Failli, Princeton Junction, NJ (US);

John P. Dusza, Nanuet, NY (US);

Thomas J. Caggiano, Morrisville, PA (US);

Jay S. Shumsky, Hightstown, NJ (US);

Kevin A. Memoli, Cranbury, NJ (US);

Eugene J. Trybulski, Princeton Junction, NJ (US);

Inventors:

Amedeo A. Failli, Princeton Junction, NJ (US);

John P. Dusza, Nanuet, NY (US);

Thomas J. Caggiano, Morrisville, PA (US);

Jay S. Shumsky, Hightstown, NJ (US);

Kevin A. Memoli, Cranbury, NJ (US);

Eugene J. Trybulski, Princeton Junction, NJ (US);

Assignee:

Wyeth, Madison, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/02 (2006.01); A61K 31/551 (2006.01);
U.S. Cl.
CPC ...
Abstract

A compound of the formulae (I) or (II): wherein:Y is a moiety selected from NR or —(CH);wherein R is hydrogen or (C-C) lower alkyl,and n is 1; (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C-C) lower alkyl, halogen, cyano, CF, hydroxy, (C-C) lower alkoxy, (C-C) lower alkoxy carbonyl, carboxy, —CONH, —CONH[(C-C) lower alkyl], —CON[(C-C) lower alkyl]; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C-C) lower alkyl, halogen or (C-C) lower alkoxy; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C-C) lower alkyl, halogen, cyano, CF, hydroxy, (C-C) lower alkoxy, or (C-C) lower alkoxy carbonyl, carboxy, —CONH, —CONH[(C-C) lower alkyl], —CON[(C-C) lower alkyl]; or (2) a 5-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C-C) lower alkyl, (C-C) lower alkoxy, or halogen; or (3) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C-C) lower alkyl, halogen, or (C-C) lower alkoxy; represents a 5-membered aromatic (unsaturated) heterocyclic ring having one sulfur atom, optionally substituted by (C-C) lower alkyl, halogen, or (C-C) lower alkoxy; Ris a moiety of the formula and R, R, R, Rand Rare, independently, selected from a group consisting of hydrogen, (C-C) lower alkyl, OCH, halogen, CF, —SCH, OCF, SCF, or CN;or a pharmaceutically acceptable salt, or pro-drug form thereof.


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