The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2008
Filed:
Dec. 04, 2002
Jorge Berlanga Acosta, Playa, Ciudad de la Habana, CU;
José I Fernández Montequin, Amargura 318 entre Aguacate y Compostela, Habana Vieja, Ciudad de la Habana, CU;
Calixto Valdés Pérez, Playa, Ciudad de la Habana, CU;
Neobalis Franco Pérez, Marianao, Ciudad del al Habana, CU;
Ingrid Rojas Constantin, Playa, Ciudad de la Habana, CU;
Héctor Santana Milián, Playa, Ciudad de la Habana, CU;
Larissa Chacón Corvea, Playa, Ciudad de la Habana, CU;
Gerardo E. Guillén Nieto, Plaza de la Revolución, Ciudad de la Habana, CU;
Luis Herrera Martínez, Playa, Ciudad de la Habana, CU;
Leonardo Canan-haden Frías, Playa, Ciudad de la Habana, CU;
Haydee Gerónimo Pérez, Playa, Ciudad de la, CU;
Jorge Sotolongo Pena, Playa, Ciudad de la, CU;
Jorge Berlanga Acosta, Playa, Ciudad de la Habana, CU;
José I Fernández Montequin, Amargura 318 entre Aguacate y Compostela, Habana Vieja, Ciudad de la Habana, CU;
Calixto Valdés Pérez, Playa, Ciudad de la Habana, CU;
Neobalis Franco Pérez, Marianao, Ciudad del al Habana, CU;
Ingrid Rojas Constantin, Playa, Ciudad de la Habana, CU;
Héctor Santana Milián, Playa, Ciudad de la Habana, CU;
Larissa Chacón Corvea, Playa, Ciudad de la Habana, CU;
Gerardo E. Guillén Nieto, Plaza de la Revolución, Ciudad de la Habana, CU;
Luis Herrera Martínez, Playa, Ciudad de la Habana, CU;
Leonardo Canan-Haden Frías, Playa, Ciudad de la Habana, CU;
Haydee Gerónimo Pérez, Playa, Ciudad de la, CU;
Jorge Sotolongo Pena, Playa, Ciudad de la, CU;
Centro de Ingeniera Genetica y Biotecnologia, Cuidad de la Habana, CU;
Abstract
The invention relates to the use of Epidermal Growth Factor (EGF) in a preferably-injectable pharmaceutical composition which is administered by means of infiltration into and around chronic cutaneous ischaemic lesions in order to prevent diabetic foot amputation. Said composition can be administered to recently-created surgical surfaces damaged by the effect of acute reperfusion with oxygenated blood following prolonged ischaemia, thereby preventing further surgical procedures and favouring the preservation of the extremity. The aforementioned composition can be used to improve (i) the cell microenvironment, thereby increasing the reparative and defensive capacity and viability of the is tissues and (ii) the cicatrisation of cutaneous ischaemic lesions, thereby stimulating cell proliferation. The invention is suitable for use in human, veterinary and experimental medicine, specifically in vascular angiology and surgery, dermatology, burn treatment and reconstructive surgery and geriatric medicine. Said composition can be used for recalcitrant ulcers which are associated with lesions in the macro and/or microvasculature, patients with inadequate lymphatic and/or venous return and ulcers or other lesions which are difficult to cicatrise and/or heal.