The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2008
Filed:
Sep. 06, 2006
Francis Joseph Carr, Aberdeen, GB;
Fiona Suzanne Adair, Aberdeen, GB;
Anita Anne Hamilton, Aberdeen, GB;
Graham Carter, Aberdeen, GB;
Francis Joseph Carr, Aberdeen, GB;
Fiona Suzanne Adair, Aberdeen, GB;
Anita Anne Hamilton, Aberdeen, GB;
Graham Carter, Aberdeen, GB;
Merck Patent GmbH, Darmstadt, DE;
Abstract
A target protein is rendered less immunogenic to a given species by (a) determining at least part of the amino acid sequence of the target protein; (b) identifying in the amino acid sequence one or more potential epitopes for T-cells ('T-cell epitopes') of the given species; and (c) modifying the amino acid sequence to eliminate at least one of the T-cell epitopes identified in step (b) to reduce the immunogenicity of the protein when exposed to the immune system of the given species.