The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2008
Filed:
Jul. 21, 2000
Toshiyuki Sakai, Kyoto, JP;
Toshiyuki Sakai, Kyoto, JP;
Toshiyuki Sakai, Kyoto, JP;
Chungai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
A 44-bp region that confers vitamin D-responsiveness to the human p27promoter in the human p27transcriptional regulatory mechanism was revealed. This region also conferred vitamin D-responsiveness to a heterogenous promoter. Moreover, it was found that vitamin Denhances the binding between the CCAAT box existing in the region and the NF-Y protein and also the binding between the Sp1 sequence (also existing in the region) and the Sp1 protein, thus inducing human p27transcription. Also revealed were methods of screening for pharmaceutical agents that regulate the expression of the p27gene using these molecular mechanisms.