The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 2008
Filed:
Jan. 23, 2007
Alain Burgos, Les Ponts-de-Ce, FR;
Jacques Tonnel, Beaucouze, FR;
Valéry Dambrin, Saint Genis-Laval, FR;
Denis Lucet, Rueil-Malmaison, FR;
Patricia Poirier, Saint Clement de la Place, FR;
Alain Burgos, Les Ponts-de-Ce, FR;
Jacques Tonnel, Beaucouze, FR;
Valéry Dambrin, Saint Genis-Laval, FR;
Denis Lucet, Rueil-Malmaison, FR;
Patricia Poirier, Saint Clement de la Place, FR;
Zach System, Avrille, FR;
Abstract
An in situ or one-pot process for the preparation of the compounds of formula (I) uses a compound of general formula (I): and includes: a) the hydrogenation of a nitrile group of the compound of general formula (II): in which Rto R4 are especially H or alkyl and n varies from 0 to 4, in the presence of a hydrogenation catalyst, a methylating agent and an organic acid as solvent, and at a temperature Ta below the initiation temperature of a reductive amination reaction, to give a primary amine from the nitrile group; and b) the reductive amination of the primary amine in the presence of hydrogen, at a temperature Tb above Ta, to give the dimethylated amine of general formula (I) by activation of the methylating age.