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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7462734 B1

PDFFull Text
Date of Patent:
Dec. 09, 2008

Filed:

Aug. 05, 2005

Process for production of optically active α-fluoro-carboxylic ester derivatives

Applicants:

Akihiro Ishii, Saitama, JP;

Hideyuki Tsuruta, Saitama, JP;

Takashi Ootsuka, Saitama, JP;

Yokusu Kuriyama, Saitama, JP;

Manabu Yasumoto, Saitama, JP;

Kenjin Inomiya, Saitama, JP;

Koji Ueda, Saitama, JP;

Inventors:

Akihiro Ishii, Saitama, JP;

Hideyuki Tsuruta, Saitama, JP;

Takashi Ootsuka, Saitama, JP;

Yokusu Kuriyama, Saitama, JP;

Manabu Yasumoto, Saitama, JP;

Kenjin Inomiya, Saitama, JP;

Koji Ueda, Saitama, JP;

Assignee:

Central Glass Company, Limited, Ube-shi, JP;

Attorney:

Crowell & Moring LLP

Primary Examiner:

Paul A Zucker

Int. Cl.
CPC ...
C07C 69/76 (2006.01); C07C 69/63 (2006.01); C07C 33/46 (2006.01); C07C 31/34 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to a process for producing an optically active α-fluorocarboxylate derivative represented by the formula [2], by reacting an optically active α-hydroxycarboxylate derivative with trifluoromethanesulfonyl fluoride (CFSOF) in the presence of an organic base, in the formula [2], R represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 12; one of or two by any combination of aromatic hydrocarbon groups, unsaturated hydrocarbon groups, straight-chain or branched alkoxy groups of a carbon number of 1 to 6, aryloxy groups, halogen atoms (fluorine, chlorine, bromine and iodine), protected carboxyl groups, protected amino groups or protected hydroxyl group can be substituted on any carbon atoms of the alkyl group; Rrepresents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 8; any carbon atoms of the alkyl groups of R and Rmay form a covalent bond; and * represents an asymmetric carbon.

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