The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 2008
Filed:
Oct. 02, 2006
Jagan N. Thurpari, Owings Mills, MD (US);
Leslie E. Landree, Baltimore, MD (US);
Gabrielle Ronnett, Lutherville, MD (US);
Francis P. Kuhajda, Lutherville, MD (US);
Jagan N. Thurpari, Owings Mills, MD (US);
Leslie E. Landree, Baltimore, MD (US);
Gabrielle Ronnett, Lutherville, MD (US);
Francis P. Kuhajda, Lutherville, MD (US);
The Johns Hopkins University School of Medicine Licensing And Technology Development, Baltimore, MD (US);
Abstract
This invention provides methods and compositions for inducing weight loss and maintaining optimum weight comprising administering an agent that stimulates carnitine palmitoyl transferase-1 (CPT-1) activity to the patient in need, including human patients. These methods do not require inhibition of fatty acid synthesis. In particular, this invention provides methods for development of therapeutics that selectively enhance fatty acid oxidation, increase energy production, and reduce adiposity while preserving lean mass, through the pharmacological stimulation of CPT-1 activity. In a preferred mode, the agent is administered in an amount sufficient to increase fatty acid oxidation. In another preferred mode, the agent is administered in an amount sufficient to antagonize malonyl CoA inhibition of CPT-1. In yet another preferred mode, the agent is administered in an amount sufficient to increase malonyl CoA level.