The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 2008
Filed:
Jun. 05, 2006
Qingping Jiang, Northborough, MA (US);
Anand Natrajan, Manchester, NH (US);
David Sharpe, Foxboro, MA (US);
Wen-jee Wong, Weston, MA (US);
Say-jong Law, Westwood, MA (US);
Qingping Jiang, Northborough, MA (US);
Anand Natrajan, Manchester, NH (US);
David Sharpe, Foxboro, MA (US);
Wen-Jee Wong, Weston, MA (US);
Say-Jong Law, Westwood, MA (US);
Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US);
Abstract
A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows:Lumi-M-P  Formula Iwhere 'Lumi' is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P is a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following: where HE is a hydrolytic enzyme. Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.