The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2008
Filed:
Feb. 01, 2006
Isidro Sanchez Garcia, Salamanca, ES;
Jesus Perez Losada, Salamanca, ES;
Isidro Sanchez Garcia, Salamanca, ES;
Jesus Perez Losada, Salamanca, ES;
Universidad de Salamanca, Salamanca, ES;
Consejo Superior de Investigaciones, Madrid, ES;
Abstract
Transgenic non-human mammals that reproduce human pathologies of stem cell origins, such as chromosomal anomalies associated with chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, T-cell acute or lymphoblastic leukemia, or with the migration of hematopoietic or embryonic stem calls. The transgenic non-human mammals can be produced using as a strategy the expression of genes involved in said pathologies by means of a promoter that directs the expression of a transgene in Sca-1cells. Said transgenic animals constitute a model for the study of said diseases and for the evaluation of compounds for the treatment and/or prevention of the diseases. Also disclosed are DNA construct and methods useful for producing the non-human transgenic mammals.