The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2008
Filed:
Feb. 20, 2004
Mahavir Prashad, Montville, NJ (US);
Hong-yong Kim, Whippany, NJ (US);
Bin HU, Green Brook, NJ (US);
Joel Slade, Flanders, NJ (US);
Prasad Koteswara Kapa, Parsippany, NJ (US);
Michael John Girgis, Montville, NJ (US);
Mahavir Prashad, Montville, NJ (US);
Hong-Yong Kim, Whippany, NJ (US);
Bin Hu, Green Brook, NJ (US);
Joel Slade, Flanders, NJ (US);
Prasad Koteswara Kapa, Parsippany, NJ (US);
Michael John Girgis, Montville, NJ (US);
Novartis AG, Basel, CH;
Abstract
Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following features: (1) make use of a particular β-lactam intermediate; (2) which make use of a particular resolving agents, enantiomerically pure substituted propionic acids, especially (R)-2-butyl-3-hydroxy-propionic acid; (3) which avoid the use of hydrogen peroxide; and (4) which facilitate selective debenzylation reducing production of waste by-products.