The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2008
Filed:
Nov. 14, 2006
Ernest J. Mceachern, White Rock, CA;
Gary J. Bridger, Bellingham, WA (US);
Krystyna A. Skupinska, New Westminster, CA;
Renato T. Skerlj, Vancouver, CA;
Wen Yang, Aldergrove, CA;
Ernest J. McEachern, White Rock, CA;
Gary J. Bridger, Bellingham, WA (US);
Krystyna A. Skupinska, New Westminster, CA;
Renato T. Skerlj, Vancouver, CA;
Wen Yang, Aldergrove, CA;
Anormed, Inc., British Columbia, CA;
Abstract
This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.