The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2008
Filed:
Aug. 12, 2005
Paul A. J. Janssen, Vosselaar, BE;
Jan Heeres, Vosselaar, BE;
Henri E. L. Moereels, Ekeren, BE;
Michael Joseph Kukla, Spring House, PA (US);
Donald W. Ludovici, Spring House, PA (US);
Paul A. J. Janssen, Vosselaar, BE;
Jan Heeres, Vosselaar, BE;
Henri E. L. Moereels, Ekeren, BE;
Michael Joseph Kukla, Spring House, PA (US);
Donald W. Ludovici, Spring House, PA (US);
Janssen Pharmaceutica, Inc., , BE;
Abstract
This invention concerns the compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein Rand Rare each independently selected from hydrogen; hydroxy; amino; optionally substituted Calkyl; Calkyloxy; Calkylcarbonyl; Calkyloxycarbonyl; Ar; mono- or di(Calkyl)amino; mono- or di(Calkyl)-aminocarbonyl; dihydro-2(3H)-furanone; or Rand Rtaken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(Calkyl)amino-Calkylidene; Ris hydrogen, Ar, Calkylcarbonyl, Calkyl, Calkyloxy-carbonyl, Calkyl substituted with Calkyloxycarbonyl; and R, R, R, Rand Rare each independently selected from hydrogen, halo, Calkyl, Calkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is optionally substituted Calkyl; Calkenyl; Calkynyl; Ccycloalkyl; Aris optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.