The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2008
Filed:
May. 19, 2003
Daniella I. Zheleva, Dundee, GB;
Peter Martin Fischer, Angus, GB;
Campbell Mcinnes, Dundee, GB;
Martin J. I. Andrews, Dundee, GB;
Weng C. Chan, Nottingham, GB;
Gail E. Atkinson, Beverley, GB;
Daniella I. Zheleva, Dundee, GB;
Peter Martin Fischer, Angus, GB;
Campbell McInnes, Dundee, GB;
Martin J. I. Andrews, Dundee, GB;
Weng C. Chan, Nottingham, GB;
Gail E. Atkinson, Beverley, GB;
Cyclacel Limited, London, GB;
Abstract
The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides are derived from a C-terminal region of p21 and display selectivity for cyclin/CDK2 inhibition over cyclin/CDK4 inhibition. Variants of such peptides particularly involving certain alanine replacements are shown to be particularly potent.