The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2008
Filed:
Oct. 24, 2005
Ghazala Hashmi, Holmdel, NJ (US);
Michael Seul, Fanwood, NJ (US);
Marion E. Reid, Jamaica Estates, NY (US);
Michael Pierce, Flemington, NJ (US);
Ghazala Hashmi, Holmdel, NJ (US);
Michael Seul, Fanwood, NJ (US);
Marion E. Reid, Jamaica Estates, NY (US);
Michael Pierce, Flemington, NJ (US);
Bio Array Solutions, Warren, NJ (US);
New York Blood Center, New York, NY (US);
Abstract
Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.