The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2008
Filed:
Sep. 13, 2004
Stephen Bryant Liggett, Cincinnati, OH (US);
Lynne Elizabeth Wagoner, Cincinnati, OH (US);
Stephen Bryant Liggett, Cincinnati, OH (US);
Lynne Elizabeth Wagoner, Cincinnati, OH (US);
University of Cincinnati, Cincinnati, OH (US);
Abstract
Methods and compositions for the detection, diagnosis, and prevention of cardiac conditions are provided. Polymorphisms of β-adrenergic receptor are provided. The Gly389 β-adrenergic receptor variants are not as responsive to treatment β blockers such as carvedilol, metoprolol or bisoprol. Thus, genotyping β-adrenergic receptor polymorphisms is useful for predicting relative responsiveness to treatment with beta blockers. The Gly389 polymorphism also may be used, alone or in conjunction with other adrenergic receptor polymorphisms, to predict relative risk of developing cardiovascular diseases such as heart failure or to predict relative survival rate in patients with heart failure or other cardiovascular diseases. Also provided are transgenic mice and transgenic cells expressing the β-adrenergic receptor polymorphisms, and their use in identifying therapeutic agents.