The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2008
Filed:
Dec. 11, 2006
Satyam Nampalli, Belle Mead, NJ (US);
Brijesh Patel, Piscataway, NJ (US);
Peter Xavier Tharial, Piscataway, NJ (US);
Ravishanker Kovi, Monroe, NJ (US);
Satyam Nampalli, Belle Mead, NJ (US);
Brijesh Patel, Piscataway, NJ (US);
Peter Xavier Tharial, Piscataway, NJ (US);
Ravishanker Kovi, Monroe, NJ (US);
Apicore, LLC, Somerset, NJ (US);
Abstract
A process for preparation of protriptyline hydrochloride from 5-dihydrobenzocycloheptatriene of formula (1) by coupling with chloropropyl alcohol in the presence of excess n-butyl Lithium in tetrahydrofuran under inert atmosphere, followed by preparation of mesylate derivative of formula (3) and finally the nucleophilic displacement of the mesylate group by reacting methylamine solution in methanol to give protriptyline free base of the formula (4). Also the present process reveals the hydrochloride salt formation and purification of the same to give pure pharmaceutical grade protriptyline hydrochloride with impurities less than 0.1% w/w.